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Accumulating evidence suggests that HD progression involves a self-reinforcing pathological, in which oxidative stress, mitochondrial dysfunction, iron accumulation, lipid peroxidation, and glutathione (GSH) depletion interact and exacerbate one another, thereby contributing to progressive neuronal damage (55)

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10.1093/brain/awq386 [DOI] [PubMed] [Google Scholar] 36.Scannevin RH, Chollate S, Jung MY, Shackett M, Patel H, Bista P, et al